CAS No.: | 1801959-12-5 |
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Formula: | C35h55n11o9 |
EINECS: | PE22-28 |
Type: | Pharmaceutical Intermediates |
Appearance: | Powder |
Quality: | Technical |
Samples: |
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Name | PE 22-28 |
CAS NO | 1801959-12-5 |
Function | PE 22-28 is a TREK-1 inhibitor with an IC50 of 0.12 nM. PE 22-28 is also a 7-amino acid peptide used as a core sequence for the preparation of analogues by chemical modification and amino acid substitution. PE 22-28 can be used in the study of depression |
Apparence | White Powder |
Package | Aluminum Bag;Drums;Paper Box Outside |
Product description
PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin which binds to TREK-1. TREK-1 is found in regions of the brain controlling mood, memory, and learning.
Usage
The receptor that spadin and thus PE-22-28 primarily bind to is TREK-1. TREK-1 is a two-pore potassium channel regulated by a number of different molecules. It belongs to a large family of two-pore potassium channels that are important in regulating the excitability of neurons. TREK-1, in particular, is found in regions of the brain controlling mood, memory, and learning. These areas include the prefrontal cortex, the amygdala, and the hippocampus. Stimulating TREK-1 activity reduces excitability of the neuron while reducing TREK-1 function increases excitability and increases the likelihood of a depolarization event. By reducing excitability of the neuron, TREK-1 can help to protect against excitotoxicity.
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