specification
Product name |
Oligopeptide P11-4 |
CAS number |
593266-60-5 |
MF |
C72H98N20O22 |
Product description
P11-4 is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel regeneration or as an oral care agent. P11-4 (INCI name Oligopeptide 104) consists of the natural occurring amino acids Glutamine, Glutamic acid, Phenylalanine, Tryptophan and Arginine. The resulting higher molecular structure has a high affinity to tooth mineral.
P11-4 is a self-assembling β-peptide. It builds a 3-D bio-matrix with binding sites for Calcium-ions serving as nucleation point for Hydroxyapatite (tooth mineral) formation. The high affinity to tooth mineral is based on matching distances of Ca-ion binding sites on P11-4 and Ca spacing in the crystal lattice of hydroxyapatite. The matrix formation is pH controlled and thus allows control matrix activity and place of formation.
Self assembling properties of P11-4 are used to regenerate early caries lesions. By application of P11-4 on the tooth surface, the peptide diffuse through the intact hypomineralized plate into the early caries lesion body and start, due to the low pH in such a lesion, to self-assemble generating a peptide scaffold mimicking the enamel matrix. Around the newly formed matrix de-novo enamel-crystals are formed from calcium phosphate present in saliva. Through the remineralization caries activity is significantly reduced in comparison with a fluoride treatment alone. In aqueous oral care gels the peptide is present as matrix. It binds directly as matrix to the tooth mineral and forms a stable layer on the teeth. This layer does protect the teeth from acid attacks. It also occludes open dentin tubule and thus reduces the dental sensitivity.
About us
MOL Changes is based on bioactive peptide R&D and production, providing high end peptide molecule biologics for pharmaceutical and cosmetic companies.
Already occupying 30% share of Melanotan-II tanning peptide in China's export market, we have passed ISO; Halal; Kosher; FDA; SGS and many other certifications for the record.
In the future, MOL Changes' vision is to become a global leading company in individual bioactive peptide products, and to establish a strong product matrix in the peptide field to help our customers take the leading position in the market.
The research and development team from Lilly and novonordisk Biopeptide research and development team has published 19 research results of life active peptides applied in the field of medical beauty in China.
The production lines meet the requirements of GMP management and realize the data monitoring of the whole process.
Relying on automated assembly line, it provides small-batch active biological peptide products for most medical and beauty institutions and laboratory pharmaceutical enterprises.
package
All products come in a box of 10 bottles.
Pack the box in a cardboard box when shipping.
Transportation and delivery
All products are delivered by express and airmail
·Small batches are sent by DHL and fedex, and the shipping time is 3-6 days to your hands.
·A large number of products are sent by air, the transportation time is 12-18 days, including tax to the door.
Certification and registration
Has passed a number of certifications
ISO9001
FDA registration
SGS
HALAL
KOF-L